Epigenomics Services

Tailored next-gen sequencing

MIcrobial Epigenomics - With our expertise,

• We explore the uncharted microbial DNA methylation systems

• Identify a wider array of DNA modifications, including N6-methyladenine (m6A), 5-methylcytosine (m5C), and N4-methylcytosine (m4C) motifs

• We provide a comprehensive report of methylation in gene regulation, virulence, and pathogen-host interactions. to facilitate differential methylation studies (methylated motifs and their corresponding methyltransferases (MTases)) across various microbial population

Methylome Profilling

Enzymatic methyl-sequencing (EM-seq) -

1. Utilizing ONT ability to produce reads of unrestricted length, which effectively preserves & directly identified DNA and RNA base modifications at single-nucleotide resolution (m6A in RNA, and 5mC, 5hmC, and 6mA in DNA) and generated comprehensive methylome profiling

2. Enhances our understanding of epigenetic regulation and its implications in various biological processes and diseases

Plant Epigenomics -

• nCATS-seq: Cas9-targeted nanopore sequencing (nCATS) & Methylome profilling

• 6mA-seq: Detection and quantification of N6-methyladenine (6mA) emerging epigenetic marker in DNA

• 6mC-seq: Popoulation epigenomics - determines phenotype and adaptation of plant poplulation to the environment

• RiboMeth-seq: 2'-O-RNA methylation sequencing service detects 2'-O-RNA methylation modifications in snoRNA, tRNA, & rRNA

• To generate a comprehensive understanding of epigenetic regulations in plant responses to the external environment

• To uncover molecular mechanisms responsible for plant growth, development, environmental stress response, which facilitates crop improvement & productivity

Animal Epigenomics -

• Ageing clock: used to infer a solution to the industry birthdate recording of animals

• ATAC-seq: used to infer the accessible nuclear chromatin regions in cattle/Bovine/Fish/rat/mouse/insect/marine invertebrates

Human Epigenomics -

• We utilize the ONT workflow to utilize PCR-free detection of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) methylation alongside SNVs, SVs, & STRs in a single streamlined assay

• Telo-seq: we accurately measure telomere length and assign each telomere to a specific chromosome arm which determines the ‘Hayflick limit’

• used to infer telomere dynamics in health and disease, offers insights into age-related disorders, cancer, industry birthdate recording of animals

Environmental Genomics Services

We analyze environmental samples to reveal insights into biodiversity, ecosystem health, & impacts of climate change

Our targeted panels

MGS-AMR

Gene-centric mining of metagenomic sequencing for antimicrobial resistance profile & pathogens

Wastewater surveillance - Disease Management Strategies

Emerged as a vital tool in identifying pathogens circulating within a community, including those strains associated with antimicrobial resistance

By analyzing wastewater samples, researchers can detect various pathogens, their prevalence and variations

Proactive approach in mitigating the impact of infectious diseases their variants, AMR on populations

Real-time monitoring of community health trends and assists in early outbreak detection

Syngenome's innovative solutions transformed our approach to sustainable biomes and advanced our genomic research significantly.

The genomic insights provided by Syngenome have been invaluable for our synthetic biology projects and sustainability goals.

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